This gene is located in the region associated with DiGeorge syndrome on chromosome 22. The encoded protein localizes to the centrosome and nucleolus and may play a role in the regulation of cell division. [provided by RefSeq, Feb 2015]
Transcription factors with Perturb-seq knockdown data for YPEL1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = YPEL1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of YPEL1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr22:21,567,510–21,568,436 | 168.1 kb | Distal (>10kb) Multiome | 951 | |
| chr22:21,628,821–21,630,259 | 105.7 kb | Distal (>10kb) Multiome | 1055 | |
| chr22:21,641,511–21,643,313 | 93.6 kb | Distal (>10kb) Multiome | 754 | |
| chr22:21,651,622–21,652,445 | 83.7 kb | Distal (>10kb) Multiome | 719 | |
| chr22:21,657,073–21,658,429 | 78.1 kb | Distal (>10kb) Multiome | 802 | |
| chr22:21,665,721–21,666,577 | 69.7 kb | Distal (>10kb) Multiome | 893 | |
| chr22:21,726,699–21,726,947 | 8.8 kb | Proximal (<10kb) | 240 | |
| chr22:21,735,345–21,736,601 | 162 bp | At TSS Multiome | 774 | |
| chr22:21,864,937–21,865,391 | 129.3 kb | Distal (>10kb) Multiome | 184 | |
| chr22:21,866,936–21,868,402 | 132.0 kb | Distal (>10kb) Multiome | 929 | |
| chr22:21,925,450–21,926,079 | 190.0 kb | Distal (>10kb) Multiome HiCAR | 169 | |
| chr22:21,938,040–21,938,786 | 202.5 kb | Distal (>10kb) Multiome HiCAR | 871 | |
| chr22:21,951,964–21,953,251 | 217.1 kb | Distal (>10kb) Multiome | 645 |
Genomic view of the YPEL1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.