The protein encoded by this gene is the human ortholog of yeast mitochondrial AAA metalloprotease, Yme1p. It is localized in the mitochondria and can functionally complement a yme1 disruptant yeast strain. It is proposed that this gene plays a role in mitochondrial protein metabolism and could be involved in mitochondrial pathologies. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
Transcription factors with Perturb-seq knockdown data for YME1L1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = YME1L1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of YME1L1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:26,860,047–26,861,781 | 293.3 kb | Distal (>10kb) Multiome | 923 | |
| chr10:26,923,645–26,924,112 | 230.5 kb | Distal (>10kb) Multiome | 66 | |
| chr10:27,015,228–27,016,107 | 138.7 kb | Distal (>10kb) Multiome | 15 | |
| chr10:27,099,907–27,101,042 | 54.0 kb | Distal (>10kb) Multiome | 756 | |
| chr10:27,153,856–27,156,360 | 948 bp | At TSS Multiome | 970 | |
| chr10:27,240,222–27,241,262 | 86.2 kb | Distal (>10kb) Multiome | 831 | |
| chr10:27,241,284–27,242,441 | 87.8 kb | Distal (>10kb) Multiome | 851 | |
| chr10:27,252,226–27,253,021 | 98.2 kb | Distal (>10kb) Multiome | 405 | |
| chr10:27,258,839–27,259,511 | 104.8 kb | Distal (>10kb) Multiome | 220 | |
| chr10:27,319,712–27,320,433 | 165.6 kb | Distal (>10kb) Multiome | 239 |
Genomic view of the YME1L1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.