Predicted to enable metal ion binding activity. Predicted to be involved in RNA splicing and negative regulation of DNA damage response, signal transduction by p53 class mediator. Part of U2-type catalytic step 1 spliceosome. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for YJU2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = YJU2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of YJU2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:3,968,623–3,969,280 | 278.2 kb | Distal (>10kb) Multiome | 547 | |
| chr19:3,970,535–3,971,713 | 275.9 kb | Distal (>10kb) Multiome | 728 | |
| chr19:3,985,032–3,985,862 | 261.6 kb | Distal (>10kb) Multiome | 932 | |
| chr19:3,987,682–3,988,217 | 259.1 kb | Distal (>10kb) Multiome | 346 | |
| chr19:4,006,992–4,008,553 | 239.5 kb | Distal (>10kb) Multiome | 888 | |
| chr19:4,064,058–4,067,782 | 181.2 kb | Distal (>10kb) Multiome | 811 | |
| chr19:4,123,681–4,124,581 | 122.9 kb | Distal (>10kb) Multiome | 798 | |
| chr19:4,182,102–4,182,890 | 64.5 kb | Distal (>10kb) Multiome | 862 | |
| chr19:4,198,066–4,198,600 | 48.8 kb | Distal (>10kb) Multiome | 214 | |
| chr19:4,246,623–4,247,617 | 204 bp | At TSS Multiome | 960 | |
| chr19:4,326,625–4,329,107 | 81.4 kb | Distal (>10kb) Multiome | 567 | |
| chr19:4,342,323–4,344,016 | 95.8 kb | Distal (>10kb) Multiome | 969 | |
| chr19:4,390,525–4,391,068 | 143.6 kb | Distal (>10kb) Multiome | 464 | |
| chr19:4,399,835–4,401,019 | 153.5 kb | Distal (>10kb) Multiome | 828 | |
| chr19:4,402,106–4,403,050 | 155.4 kb | Distal (>10kb) Multiome | 731 | |
| chr19:4,456,541–4,458,172 | 210.7 kb | Distal (>10kb) Multiome | 757 | |
| chr19:4,471,202–4,472,545 | 224.9 kb | Distal (>10kb) Multiome | 715 | |
| chr19:4,474,252–4,474,874 | 227.6 kb | Distal (>10kb) Multiome | 201 | |
| chr19:4,534,817–4,535,416 | 288.2 kb | Distal (>10kb) Multiome | 451 |
Genomic view of the YJU2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.