This gene encodes a nucleic acid binding protein which is highly expressed in germ cells. The encoded protein binds to a Y-box element in the promoters of certain genes but also binds to mRNA transcribed from these genes. Pseudogenes for this gene are located on chromosome 10 and 15. [provided by RefSeq, Feb 2012]
Transcription factors with Perturb-seq knockdown data for YBX2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = YBX2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of YBX2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:6,995,886–6,996,299 | 298.7 kb | Distal (>10kb) Multiome | 124 | |
| chr17:7,012,245–7,012,890 | 282.1 kb | Distal (>10kb) Multiome | 804 | |
| chr17:7,014,335–7,015,213 | 279.8 kb | Distal (>10kb) Multiome | 842 | |
| chr17:7,021,831–7,024,265 | 270.7 kb | Distal (>10kb) Multiome | 614 | |
| chr17:7,035,527–7,036,637 | 258.7 kb | Distal (>10kb) Multiome | 791 | |
| chr17:7,132,532–7,133,109 | 161.8 kb | Distal (>10kb) Multiome | 312 | |
| chr17:7,177,263–7,177,909 | 117.1 kb | Distal (>10kb) Multiome | 453 | |
| chr17:7,204,820–7,205,551 | 89.5 kb | Distal (>10kb) Multiome | 364 | |
| chr17:7,207,943–7,208,476 | 86.4 kb | Distal (>10kb) Multiome | 91 | |
| chr17:7,213,858–7,216,461 | 80.1 kb | Distal (>10kb) Multiome | 737 | |
| chr17:7,219,603–7,220,515 | 74.7 kb | Distal (>10kb) Multiome | 793 | |
| chr17:7,233,847–7,235,210 | 60.1 kb | Distal (>10kb) Multiome | 1020 | |
| chr17:7,237,531–7,238,757 | 56.7 kb | Distal (>10kb) Multiome | 502 | |
| chr17:7,238,867–7,240,155 | 54.9 kb | Distal (>10kb) Multiome | 783 | |
| chr17:7,241,494–7,243,462 | 52.1 kb | Distal (>10kb) Multiome | 1037 | |
| chr17:7,251,263–7,252,962 | 42.5 kb | Distal (>10kb) Multiome | 985 | |
| chr17:7,260,746–7,263,748 | 32.0 kb | Distal (>10kb) Multiome | 639 | |
| chr17:7,280,161–7,282,555 | 13.0 kb | Distal (>10kb) Multiome | 841 | |
| chr17:7,293,901–7,295,189 | 138 bp | At TSS Multiome | 443 | |
| chr17:7,296,224–7,296,683 | 1.9 kb | Proximal (<10kb) Multiome | 688 | |
| chr17:7,306,788–7,309,027 | 12.8 kb | Distal (>10kb) Multiome | 896 | |
| chr17:7,314,722–7,315,725 | 20.7 kb | Distal (>10kb) Multiome | 843 | |
| chr17:7,328,881–7,330,972 | 35.8 kb | Distal (>10kb) Multiome | 809 | |
| chr17:7,349,378–7,350,590 | 55.6 kb | Distal (>10kb) Multiome | 414 | |
| chr17:7,351,208–7,352,575 | 57.4 kb | Distal (>10kb) Multiome | 857 | |
| chr17:7,356,082–7,356,523 | 61.7 kb | Distal (>10kb) Multiome | 485 | |
| chr17:7,383,791–7,384,537 | 89.6 kb | Distal (>10kb) Multiome | 218 | |
| chr17:7,393,924–7,395,223 | 100.0 kb | Distal (>10kb) Multiome | 744 | |
| chr17:7,403,290–7,405,695 | 109.7 kb | Distal (>10kb) Multiome | 838 | |
| chr17:7,435,167–7,437,681 | 140.8 kb | Distal (>10kb) Multiome | 828 | |
| chr17:7,440,048–7,441,211 | 146.1 kb | Distal (>10kb) Multiome | 487 | |
| chr17:7,444,968–7,446,142 | 151.0 kb | Distal (>10kb) Multiome | 632 | |
| chr17:7,455,450–7,456,019 | 161.0 kb | Distal (>10kb) Multiome | 414 | |
| chr17:7,478,839–7,480,126 | 184.8 kb | Distal (>10kb) Multiome | 574 | |
| chr17:7,483,139–7,485,576 | 189.8 kb | Distal (>10kb) Multiome | 1156 | |
| chr17:7,560,249–7,562,536 | 267.4 kb | Distal (>10kb) Multiome | 759 | |
| chr17:7,572,039–7,574,418 | 278.0 kb | Distal (>10kb) Multiome | 1071 | |
| chr17:7,579,018–7,579,876 | 284.8 kb | Distal (>10kb) Multiome | 844 | |
| chr17:7,583,063–7,584,547 | 289.2 kb | Distal (>10kb) Multiome | 921 | |
| chr17:7,588,871–7,590,534 | 295.6 kb | Distal (>10kb) Multiome | 319 |
Genomic view of the YBX2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.