YBX2
Y-box binding protein 2 | CSDA3, Contrin, MSY2

This gene encodes a nucleic acid binding protein which is highly expressed in germ cells. The encoded protein binds to a Y-box element in the promoters of certain genes but also binds to mRNA transcribed from these genes. Pseudogenes for this gene are located on chromosome 10 and 15. [provided by RefSeq, Feb 2012]

Biological processes 13 terms
Expression (TPM)
YBX2 — as a Regulated Gene

TFs regulating YBX2 0 TFs

Transcription factors with Perturb-seq knockdown data for YBX2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = YBX2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to YBX2

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of YBX2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr17:6,995,886–6,996,299 298.7 kb Distal (>10kb) Multiome 124
chr17:7,012,245–7,012,890 282.1 kb Distal (>10kb) Multiome 804
chr17:7,014,335–7,015,213 279.8 kb Distal (>10kb) Multiome 842
chr17:7,021,831–7,024,265 270.7 kb Distal (>10kb) Multiome 614
chr17:7,035,527–7,036,637 258.7 kb Distal (>10kb) Multiome 791
chr17:7,132,532–7,133,109 161.8 kb Distal (>10kb) Multiome 312
chr17:7,177,263–7,177,909 117.1 kb Distal (>10kb) Multiome 453
chr17:7,204,820–7,205,551 89.5 kb Distal (>10kb) Multiome 364
chr17:7,207,943–7,208,476 86.4 kb Distal (>10kb) Multiome 91
chr17:7,213,858–7,216,461 80.1 kb Distal (>10kb) Multiome 737
chr17:7,219,603–7,220,515 74.7 kb Distal (>10kb) Multiome 793
chr17:7,233,847–7,235,210 60.1 kb Distal (>10kb) Multiome 1020
chr17:7,237,531–7,238,757 56.7 kb Distal (>10kb) Multiome 502
chr17:7,238,867–7,240,155 54.9 kb Distal (>10kb) Multiome 783
chr17:7,241,494–7,243,462 52.1 kb Distal (>10kb) Multiome 1037
chr17:7,251,263–7,252,962 42.5 kb Distal (>10kb) Multiome 985
chr17:7,260,746–7,263,748 32.0 kb Distal (>10kb) Multiome 639
chr17:7,280,161–7,282,555 13.0 kb Distal (>10kb) Multiome 841
chr17:7,293,901–7,295,189 138 bp At TSS Multiome 443
chr17:7,296,224–7,296,683 1.9 kb Proximal (<10kb) Multiome 688
chr17:7,306,788–7,309,027 12.8 kb Distal (>10kb) Multiome 896
chr17:7,314,722–7,315,725 20.7 kb Distal (>10kb) Multiome 843
chr17:7,328,881–7,330,972 35.8 kb Distal (>10kb) Multiome 809
chr17:7,349,378–7,350,590 55.6 kb Distal (>10kb) Multiome 414
chr17:7,351,208–7,352,575 57.4 kb Distal (>10kb) Multiome 857
chr17:7,356,082–7,356,523 61.7 kb Distal (>10kb) Multiome 485
chr17:7,383,791–7,384,537 89.6 kb Distal (>10kb) Multiome 218
chr17:7,393,924–7,395,223 100.0 kb Distal (>10kb) Multiome 744
chr17:7,403,290–7,405,695 109.7 kb Distal (>10kb) Multiome 838
chr17:7,435,167–7,437,681 140.8 kb Distal (>10kb) Multiome 828
chr17:7,440,048–7,441,211 146.1 kb Distal (>10kb) Multiome 487
chr17:7,444,968–7,446,142 151.0 kb Distal (>10kb) Multiome 632
chr17:7,455,450–7,456,019 161.0 kb Distal (>10kb) Multiome 414
chr17:7,478,839–7,480,126 184.8 kb Distal (>10kb) Multiome 574
chr17:7,483,139–7,485,576 189.8 kb Distal (>10kb) Multiome 1156
chr17:7,560,249–7,562,536 267.4 kb Distal (>10kb) Multiome 759
chr17:7,572,039–7,574,418 278.0 kb Distal (>10kb) Multiome 1071
chr17:7,579,018–7,579,876 284.8 kb Distal (>10kb) Multiome 844
chr17:7,583,063–7,584,547 289.2 kb Distal (>10kb) Multiome 921
chr17:7,588,871–7,590,534 295.6 kb Distal (>10kb) Multiome 319

Genome Browser

Genomic view of the YBX2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr17:6,985,886 – 7,600,534
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq