This gene encodes a highly conserved metalloprotein. A similar protein in bacteria acts as an endoribonuclease, and is thought to function in ribosomal RNA maturation and ribosome assembly. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
Transcription factors with Perturb-seq knockdown data for YBEY. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = YBEY upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of YBEY, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr21:46,097,574–46,098,972 | 188.3 kb | Distal (>10kb) Multiome | 294 | |
| chr21:46,153,138–46,153,696 | 133.0 kb | Distal (>10kb) Multiome | 515 | |
| chr21:46,184,645–46,185,202 | 101.7 kb | Distal (>10kb) Multiome | 334 | |
| chr21:46,228,249–46,230,022 | 57.4 kb | Distal (>10kb) Multiome | 833 | |
| chr21:46,285,753–46,286,753 | 4 bp | At TSS Multiome | 983 | |
| chr21:46,323,408–46,325,506 | 37.7 kb | Distal (>10kb) Multiome | 952 | |
| chr21:46,457,952–46,459,810 | 172.4 kb | Distal (>10kb) Multiome | 880 |
Genomic view of the YBEY locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.