XRCC6

X-ray repair cross complementing 6 | D22S671, D22S731, KU70, ML8, G22P1

The p70/p80 autoantigen is a nuclear complex consisting of two subunits with molecular masses of approximately 70 and 80 kDa. The complex functions as a single-stranded DNA-dependent ATP-dependent helicase. The complex may be involved in the repair of nonhomologous DNA ends such as that required for double-strand break repair, transposition, and V(D)J recombination. High levels of autoantibodies to p70 and p80 have been found in some patients with systemic lupus erythematosus. [provided by RefSeq, Jul 2008]

Member of: DE-1 Developmental clusters: GC4

Biological processes 71 terms

3'-5' DNA helicase activity (GO:0043138)5'-deoxyribose-5-phosphate lyase activity (GO:0051575)ATP hydrolysis activity (GO:0016887)ATP hydrolysis activity (GO:0016887)ATP-dependent activity, acting on DNA (GO:0008094)DNA binding (GO:0003677)DNA binding (GO:0003677)DNA end binding (GO:0045027)DNA helicase activity (GO:0003678)DNA helicase activity (GO:0003678)DNA-dependent protein kinase-DNA ligase 4 complex (GO:0005958)Ku70:Ku80 complex (GO:0043564)Ku70:Ku80 complex (GO:0043564)Ku70:Ku80 complex (GO:0043564)RNA binding (GO:0003723)activation of innate immune response (GO:0002218)cellular hyperosmotic salinity response (GO:0071475)cellular response to X-ray (GO:0071481)cellular response to gamma radiation (GO:0071480)chromosome (GO:0005694)chromosome, telomeric region (GO:0000781)class I DNA-(apurinic or apyrimidinic site) endonuclease activity (GO:0140078)cyclin binding (GO:0030332)cytoplasm (GO:0005737)cytosol (GO:0005829)damaged DNA binding (GO:0003684)double-strand break repair via classical nonhomologous end joining (GO:0097680)double-strand break repair via nonhomologous end joining (GO:0006303)double-strand break repair via nonhomologous end joining (GO:0006303)double-strand break repair via nonhomologous end joining (GO:0006303)double-strand break repair via nonhomologous end joining (GO:0006303)double-strand break repair via nonhomologous end joining (GO:0006303)double-stranded DNA binding (GO:0003690)double-stranded DNA binding (GO:0003690)double-stranded DNA binding (GO:0003690)double-stranded telomeric DNA binding (GO:0003691)extracellular region (GO:0005576)ficolin-1-rich granule lumen (GO:1904813)immune system process (GO:0002376)membrane (GO:0016020)membrane (GO:0016020)negative regulation of DNA-templated transcription (GO:0045892)nonhomologous end joining complex (GO:0070419)nuclear telomere cap complex (GO:0000783)nucleolus (GO:0005730)nucleoplasm (GO:0005654)nucleoplasm (GO:0005654)nucleus (GO:0005634)nucleus (GO:0005634)positive regulation of DNA-templated transcription (GO:0045893)positive regulation of DNA-templated transcription (GO:0045893)positive regulation of immune system process (GO:0002684)positive regulation of lymphocyte differentiation (GO:0045621)positive regulation of transcription by RNA polymerase II (GO:0045944)protein binding (GO:0005515)protein-DNA complex (GO:0032993)protein-containing complex (GO:0032991)protein-containing complex (GO:0032991)protein-containing complex binding (GO:0044877)recombinational repair (GO:0000725)regulation of smooth muscle cell proliferation (GO:0048660)response to ionizing radiation (GO:0010212)scaffold protein binding (GO:0097110)secretory granule lumen (GO:0034774)telomere maintenance (GO:0000723)telomere maintenance (GO:0000723)telomere maintenance (GO:0000723)telomeric repeat DNA binding (GO:0042162)telomeric repeat DNA binding (GO:0042162)transcription cis-regulatory region binding (GO:0000976)transcription regulator complex (GO:0005667)

Expression (TPM)

TFs regulating XRCC6 0 TFs

Transcription factors with Perturb-seq knockdown data for XRCC6. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = XRCC6 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to XRCC6

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of XRCC6, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr22:41,380,458–41,382,737	239.6 kb	Distal (>10kb) Multiome	925
chr22:41,413,486–41,414,305	207.4 kb	Distal (>10kb) Multiome	832
chr22:41,444,084–41,445,743	176.7 kb	Distal (>10kb) Multiome	607
chr22:41,446,165–41,449,007	174.4 kb	Distal (>10kb) Multiome	1188
chr22:41,468,341–41,469,602	152.3 kb	Distal (>10kb) Multiome	920
chr22:41,512,659–41,513,151	108.3 kb	Distal (>10kb) Multiome	354
chr22:41,543,855–41,544,782	76.7 kb	Distal (>10kb) Multiome	755
chr22:41,589,188–41,590,530	31.3 kb	Distal (>10kb) Multiome	758
chr22:41,620,173–41,622,049	150 bp	At TSS Multiome	880
chr22:41,666,496–41,667,405	45.6 kb	Distal (>10kb) Multiome	725
chr22:41,697,169–41,697,792	76.1 kb	Distal (>10kb) Multiome	464
chr22:41,800,274–41,801,345	179.3 kb	Distal (>10kb) Multiome	816
chr22:41,832,291–41,834,215	211.6 kb	Distal (>10kb) Multiome	1023
chr22:41,845,927–41,846,489	224.8 kb	Distal (>10kb) Multiome	271
chr22:41,909,821–41,910,788	289.0 kb	Distal (>10kb) Multiome	251
chr22:41,913,915–41,914,497	292.9 kb	Distal (>10kb) Multiome	143
chr22:41,914,624–41,915,454	293.8 kb	Distal (>10kb) Multiome	273
chr22:41,919,501–41,920,436	298.7 kb	Distal (>10kb) Multiome	337

Genome Browser

Genomic view of the XRCC6 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.