This gene encodes a zinc finger protein plays a central role in nucleotide excision repair (NER), a specialized type of DNA repair. NER is responsible for repair of UV radiation-induced photoproducts and DNA adducts induced by chemical carcinogens and chemotherapeutic drugs. The encoded protein interacts with DNA and several NER proteins, acting as a scaffold to assemble the NER incision complex at sites of DNA damage. Mutations in this gene cause Xeroderma pigmentosum complementation group A (XP-A), an autosomal recessive skin disorder featuring hypersensitivity to sunlight and increased risk for skin cancer. [provided by RefSeq, Aug 2017]
Transcription factors with Perturb-seq knockdown data for XPA. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = XPA upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of XPA, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:97,411,603–97,412,682 | 285.3 kb | Distal (>10kb) Multiome | 864 | |
| chr9:97,436,823–97,437,760 | 259.9 kb | Distal (>10kb) Multiome | 98 | |
| chr9:97,501,163–97,503,374 | 195.8 kb | Distal (>10kb) Multiome | 581 | |
| chr9:97,528,160–97,528,802 | 168.8 kb | Distal (>10kb) Multiome | 118 | |
| chr9:97,598,751–97,599,712 | 98.3 kb | Distal (>10kb) Multiome | 274 | |
| chr9:97,632,371–97,634,267 | 63.9 kb | Distal (>10kb) Multiome | 1027 | |
| chr9:97,696,750–97,697,733 | 20 bp | At TSS Multiome | 836 | |
| chr9:97,710,703–97,711,693 | 13.9 kb | Distal (>10kb) Multiome | 257 | |
| chr9:97,741,053–97,741,796 | 44.1 kb | Distal (>10kb) Multiome | 305 | |
| chr9:97,803,235–97,804,055 | 106.3 kb | Distal (>10kb) Multiome | 679 | |
| chr9:97,853,103–97,855,002 | 156.7 kb | Distal (>10kb) Multiome | 323 | |
| chr9:97,922,022–97,923,085 | 225.1 kb | Distal (>10kb) Multiome | 1110 | |
| chr9:97,982,380–97,985,451 | 287.4 kb | Distal (>10kb) Multiome | 994 |
Genomic view of the XPA locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.