Predicted to be involved in apoptotic process involved in development; engulfment of apoptotic cell; and phosphatidylserine exposure on apoptotic cell surface. Predicted to be located in membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for XKR6. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = XKR6 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of XKR6, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:10,928,278–10,929,029 | 272.7 kb | Distal (>10kb) Multiome | 503 | |
| chr8:11,015,417–11,017,389 | 184.8 kb | Distal (>10kb) Multiome | 681 | |
| chr8:11,047,960–11,048,530 | 153.1 kb | Distal (>10kb) Multiome | 130 | |
| chr8:11,059,056–11,059,876 | 141.9 kb | Distal (>10kb) Multiome | 226 | |
| chr8:11,200,019–11,201,991 | 158 bp | At TSS Multiome | 601 | |
| chr8:11,246,809–11,247,816 | 45.9 kb | Distal (>10kb) Multiome | 167 | |
| chr8:11,283,848–11,285,272 | 83.2 kb | Distal (>10kb) Multiome | 985 | |
| chr8:11,346,754–11,348,253 | 146.2 kb | Distal (>10kb) Multiome | 547 | |
| chr8:11,439,886–11,440,775 | 239.0 kb | Distal (>10kb) Multiome | 160 | |
| chr8:11,466,250–11,468,072 | 266.4 kb | Distal (>10kb) Multiome | 594 |
Genomic view of the XKR6 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.