Involved in DNA-templated transcription; mRNA splicing, via spliceosome; and transcription-coupled nucleotide-excision repair. Located in nucleoplasm. Part of U2-type catalytic step 2 spliceosome. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for XAB2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = XAB2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of XAB2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:7,394,774–7,395,629 | 234.5 kb | Distal (>10kb) Multiome | 601 | |
| chr19:7,482,657–7,483,489 | 146.4 kb | Distal (>10kb) Multiome | 201 | |
| chr19:7,488,712–7,489,463 | 140.5 kb | Distal (>10kb) Multiome | 542 | |
| chr19:7,500,843–7,501,401 | 128.4 kb | Distal (>10kb) Multiome | 556 | |
| chr19:7,505,850–7,507,270 | 123.0 kb | Distal (>10kb) Multiome | 516 | |
| chr19:7,507,812–7,508,356 | 121.5 kb | Distal (>10kb) Multiome | 168 | |
| chr19:7,522,263–7,523,208 | 107.0 kb | Distal (>10kb) Multiome | 917 | |
| chr19:7,533,976–7,536,472 | 95.5 kb | Distal (>10kb) Multiome | 882 | |
| chr19:7,550,673–7,551,762 | 78.2 kb | Distal (>10kb) Multiome | 377 | |
| chr19:7,554,651–7,555,821 | 74.3 kb | Distal (>10kb) Multiome | 224 | |
| chr19:7,595,485–7,596,417 | 33.8 kb | Distal (>10kb) Multiome | 405 | |
| chr19:7,629,285–7,629,891 | 134 bp | At TSS Multiome | 650 | |
| chr19:7,636,753–7,637,571 | 7.5 kb | Proximal (<10kb) Multiome | 689 | |
| chr19:7,680,480–7,681,546 | 51.2 kb | Distal (>10kb) Multiome | 679 | |
| chr19:7,829,238–7,830,666 | 200.3 kb | Distal (>10kb) Multiome | 621 | |
| chr19:7,853,168–7,853,781 | 223.9 kb | Distal (>10kb) Multiome | 747 | |
| chr19:7,861,607–7,864,383 | 233.2 kb | Distal (>10kb) Multiome | 348 | |
| chr19:7,868,454–7,870,252 | 239.9 kb | Distal (>10kb) Multiome | 721 | |
| chr19:7,871,072–7,872,772 | 242.6 kb | Distal (>10kb) Multiome | 487 | |
| chr19:7,873,962–7,875,061 | 245.1 kb | Distal (>10kb) Multiome | 416 | |
| chr19:7,888,334–7,888,798 | 258.9 kb | Distal (>10kb) Multiome | 509 | |
| chr19:7,902,730–7,904,931 | 274.2 kb | Distal (>10kb) Multiome | 1000 | |
| chr19:7,917,358–7,918,182 | 288.4 kb | Distal (>10kb) Multiome | 316 | |
| chr19:7,919,934–7,921,640 | 291.1 kb | Distal (>10kb) Multiome | 802 | |
| chr19:7,924,612–7,926,698 | 295.7 kb | Distal (>10kb) Multiome | 766 |
Genomic view of the XAB2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.