WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein which contains 4 tandem WW domains and a HECT (homologous to the E6-associated protein carboxyl terminus) domain. The encoded protein belongs to a family of NEDD4-like proteins, which are E3 ubiquitin-ligase molecules and regulate key trafficking decisions, including targeting of proteins to proteosomes or lysosomes. Alternative splicing of this gene generates at least 6 transcript variants; however, the full length nature of these transcripts has not been defined. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for WWP1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = WWP1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of WWP1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:86,068,911–86,069,915 | 273.3 kb | Distal (>10kb) Multiome HiCAR | 240 | |
| chr8:86,341,875–86,343,541 | 220 bp | At TSS Multiome | 788 | |
| chr8:86,349,932–86,350,230 | 7.2 kb | Proximal (<10kb) | 27 | |
| chr8:86,351,316–86,351,674 | 8.5 kb | Proximal (<10kb) | 19 | |
| chr8:86,507,940–86,509,282 | 165.9 kb | Distal (>10kb) Multiome | 906 | |
| chr8:86,513,900–86,515,341 | 171.7 kb | Distal (>10kb) Multiome | 716 |
Genomic view of the WWP1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.