The Wilms tumor suppressor gene WT1 appears to play a role in both transcriptional and posttranscriptional regulation of certain cellular genes. This gene encodes a WT1-associating protein, which is a ubiquitously expressed nuclear protein. Like WT1 protein, this protein is localized throughout the nucleoplasm as well as in speckles and partially colocalizes with splicing factors. Alternative splicing of this gene results in several transcript variants encoding three different isoforms. [provided by RefSeq, Jul 2012]
Transcription factors with Perturb-seq knockdown data for WTAP. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = WTAP upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of WTAP, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:159,168,575–159,170,383 | 558.1 kb | Distal (>10kb) Multiome HiCAR | 353 | |
| chr6:159,692,373–159,694,256 | 34.1 kb | Distal (>10kb) Multiome | 1061 | |
| chr6:159,718,734–159,718,968 | 8.5 kb | Proximal (<10kb) | 50 | |
| chr6:159,719,070–159,719,310 | 8.2 kb | Proximal (<10kb) | 20 | |
| chr6:159,720,715–159,720,950 | 6.6 kb | Proximal (<10kb) | 61 | |
| chr6:159,726,454–159,728,172 | 272 bp | At TSS Multiome | 1218 | |
| chr6:159,761,181–159,763,111 | 34.7 kb | Distal (>10kb) Multiome | 1026 | |
| chr6:159,788,809–159,791,272 | 62.3 kb | Distal (>10kb) Multiome | 1073 | |
| chr6:159,968,449–159,970,213 | 241.5 kb | Distal (>10kb) Multiome | 961 |
Genomic view of the WTAP locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.