The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It is very conserved in evolution, and the protein encoded by this gene is known to be 98% identical to the mouse Wnt1 protein at the amino acid level. The studies in mouse indicate that the Wnt1 protein functions in the induction of the mesencephalon and cerebellum. This gene was originally considered as a candidate gene for Joubert syndrome, an autosomal recessive disorder with cerebellar hypoplasia as a leading feature. However, further studies suggested that the gene mutations might not have a significant role in Joubert syndrome. This gene is clustered with another family member, WNT10B, in the chromosome 12q13 region. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for WNT1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = WNT1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of WNT1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:48,969,884–48,970,343 | 8.0 kb | Proximal (<10kb) | 254 | |
| chr12:48,971,536–48,971,866 | 6.5 kb | Proximal (<10kb) | 258 | |
| chr12:48,974,156–48,974,361 | 4.0 kb | Proximal (<10kb) | 158 | |
| chr12:48,978,055–48,978,819 | at TSS | At TSS | 360 | |
| chr12:48,980,647–48,981,153 | 2.3 kb | Proximal (<10kb) | 259 | |
| chr12:48,986,693–48,987,241 | 8.4 kb | Proximal (<10kb) | 65 | |
| chr12:48,988,160–48,988,373 | 9.8 kb | Proximal (<10kb) | 177 |
Genomic view of the WNT1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.