Enables several functions, including RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; histone methyltransferase binding activity; and transcription corepressor binding activity. Involved in positive regulation of nuclear cell cycle DNA replication and protein stabilization. Located in midbody and nucleoplasm. Biomarker of atherosclerosis. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for WIZ. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = WIZ upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of WIZ, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:15,124,546–15,126,107 | 307.1 kb | Distal (>10kb) Multiome HiCAR | 949 | |
| chr19:15,177,520–15,178,026 | 255.1 kb | Distal (>10kb) Multiome | 499 | |
| chr19:15,180,886–15,181,623 | 251.5 kb | Distal (>10kb) Multiome | 355 | |
| chr19:15,195,187–15,196,375 | 236.6 kb | Distal (>10kb) Multiome | 408 | |
| chr19:15,199,629–15,201,437 | 232.7 kb | Distal (>10kb) Multiome | 398 | |
| chr19:15,222,727–15,224,168 | 209.3 kb | Distal (>10kb) Multiome | 521 | |
| chr19:15,231,632–15,233,858 | 199.5 kb | Distal (>10kb) Multiome | 414 | |
| chr19:15,324,741–15,325,392 | 107.8 kb | Distal (>10kb) Multiome | 183 | |
| chr19:15,331,471–15,332,992 | 100.2 kb | Distal (>10kb) Multiome | 641 | |
| chr19:15,378,833–15,380,802 | 52.9 kb | Distal (>10kb) Multiome | 913 | |
| chr19:15,418,493–15,419,441 | 13.6 kb | Distal (>10kb) Multiome | 892 | |
| chr19:15,432,448–15,433,787 | 109 bp | At TSS Multiome | 766 | |
| chr19:15,449,146–15,450,281 | 17.1 kb | Distal (>10kb) Multiome | 446 | |
| chr19:15,451,962–15,453,427 | 19.7 kb | Distal (>10kb) Multiome | 428 | |
| chr19:15,456,680–15,457,763 | 24.4 kb | Distal (>10kb) Multiome | 240 | |
| chr19:15,555,803–15,556,689 | 123.3 kb | Distal (>10kb) Multiome | 669 | |
| chr19:16,075,837–16,077,586 | 643.6 kb | Distal (>10kb) Multiome HiCAR | 735 | |
| chr19:16,184,971–16,186,029 | 752.6 kb | Distal (>10kb) Multiome HiCAR | 658 | |
| chr19:16,197,472–16,198,501 | 765.1 kb | Distal (>10kb) Multiome HiCAR | 806 |
Genomic view of the WIZ locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.