This gene encodes a WD40 repeat protein. Members of the WD40 repeat family are key components of many essential biologic functions. They regulate the assembly of multiprotein complexes by presenting a beta-propeller platform for simultaneous and reversible protein-protein interactions. Members of the WIPI subfamily of WD40 repeat proteins have a 7-bladed propeller structure and contain a conserved motif for interaction with phospholipids. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]
Transcription factors with Perturb-seq knockdown data for WIPI1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = WIPI1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of WIPI1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:68,101,069–68,102,208 | 355.9 kb | Distal (>10kb) Multiome HiCAR | 934 | |
| chr17:68,169,087–68,169,738 | 288.1 kb | Distal (>10kb) Multiome HiCAR | 34 | |
| chr17:68,195,930–68,196,516 | 261.4 kb | Distal (>10kb) Multiome | 132 | |
| chr17:68,198,840–68,199,804 | 258.1 kb | Distal (>10kb) Multiome | 254 | |
| chr17:68,200,632–68,201,332 | 256.5 kb | Distal (>10kb) Multiome | 510 | |
| chr17:68,205,092–68,206,268 | 252.0 kb | Distal (>10kb) Multiome | 867 | |
| chr17:68,247,371–68,248,543 | 209.6 kb | Distal (>10kb) Multiome HiCAR | 986 | |
| chr17:68,291,089–68,292,878 | 166.1 kb | Distal (>10kb) Multiome HiCAR | 972 | |
| chr17:68,456,319–68,458,376 | 220 bp | At TSS Multiome | 914 | |
| chr17:68,462,644–68,463,284 | 5.6 kb | Proximal (<10kb) Multiome | 394 | |
| chr17:68,465,850–68,466,410 | 8.3 kb | Proximal (<10kb) | 352 | |
| chr17:68,511,401–68,513,461 | 54.8 kb | Distal (>10kb) Multiome | 1112 | |
| chr17:68,599,584–68,601,475 | 142.8 kb | Distal (>10kb) Multiome | 707 | |
| chr17:68,700,732–68,701,756 | 243.7 kb | Distal (>10kb) Multiome | 188 | |
| chr17:68,732,063–68,732,967 | 275.0 kb | Distal (>10kb) Multiome | 284 |
Genomic view of the WIPI1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.