Predicted to enable alpha-tubulin binding activity and gamma-tubulin binding activity. Predicted to be involved in Arp2/3 complex-mediated actin nucleation; endosomal transport; and exocytosis. Predicted to be located in cytosol. Predicted to be part of WASH complex. Predicted to be active in early endosome; recycling endosome; and synapse. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for WIPF3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = WIPF3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of WIPF3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:29,562,877–29,564,500 | 242.6 kb | Distal (>10kb) Multiome | 603 | |
| chr7:29,684,580–29,685,711 | 121.3 kb | Distal (>10kb) Multiome | 317 | |
| chr7:29,793,536–29,794,092 | 12.7 kb | Distal (>10kb) Multiome | 300 | |
| chr7:29,805,967–29,807,849 | 39 bp | At TSS Multiome | 418 | |
| chr7:29,883,518–29,884,842 | 77.7 kb | Distal (>10kb) Multiome | 244 | |
| chr7:29,988,902–29,990,326 | 183.3 kb | Distal (>10kb) Multiome | 631 | |
| chr7:30,026,273–30,027,418 | 220.3 kb | Distal (>10kb) Multiome | 750 | |
| chr7:30,027,667–30,029,334 | 221.9 kb | Distal (>10kb) Multiome | 888 |
Genomic view of the WIPF3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.