This gene is thought to function in the organization and stabilization of sterocilia elongation and actin cystoskeletal assembly, based on studies of the related mouse gene. Mutations in this gene have been associated with autosomal recessive non-syndromic deafness and Usher Syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2016]
Transcription factors with Perturb-seq knockdown data for WHRN. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = WHRN upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of WHRN, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:114,370,337–114,371,120 | 134.9 kb | Distal (>10kb) Multiome | 151 | |
| chr9:114,387,530–114,388,416 | 117.4 kb | Distal (>10kb) Multiome | 315 | |
| chr9:114,397,621–114,398,973 | 107.1 kb | Distal (>10kb) Multiome | 744 | |
| chr9:114,405,604–114,406,064 | 99.7 kb | Distal (>10kb) Multiome | 266 | |
| chr9:114,409,093–114,409,699 | 96.2 kb | Distal (>10kb) Multiome | 85 | |
| chr9:114,501,767–114,502,643 | 2.8 kb | Proximal (<10kb) | 262 | |
| chr9:114,504,150–114,506,064 | 120 bp | At TSS Multiome | 672 | |
| chr9:114,583,376–114,584,037 | 78.2 kb | Distal (>10kb) Multiome HiCAR | 117 | |
| chr9:114,587,169–114,588,239 | 82.2 kb | Distal (>10kb) Multiome | 922 | |
| chr9:114,610,961–114,612,019 | 106.0 kb | Distal (>10kb) Multiome | 923 | |
| chr9:114,799,438–114,800,403 | 294.5 kb | Distal (>10kb) Multiome | 162 |
Genomic view of the WHRN locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.