This gene encodes a protein that plays a role in actin nucleation, Golgi membrane association and microtubule binding. The encoded protein is a nucleation-promoting factor that regulates the Actin-related protein 2/3 complex. The activated complex initiates growth of new actin filaments by binding to existing actin filaments. The encoded protein also functions in regulation of transport from the endoplasmic reticulum to the Golgi complex and in maintenance of the Golgi complex near the centrosome. Four pseudogenes of this gene are present on the same arm of chromosome 15 as this gene. [provided by RefSeq, Aug 2013]
Transcription factors with Perturb-seq knockdown data for WHAMM. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = WHAMM upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of WHAMM, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:82,571,710–82,572,201 | 237.8 kb | Distal (>10kb) Multiome | 194 | |
| chr15:82,647,462–82,648,736 | 161.5 kb | Distal (>10kb) Multiome | 511 | |
| chr15:82,679,753–82,681,281 | 129.1 kb | Distal (>10kb) Multiome | 495 | |
| chr15:82,708,766–82,710,416 | 99.9 kb | Distal (>10kb) Multiome | 725 | |
| chr15:82,750,200–82,750,777 | 59.1 kb | Distal (>10kb) Multiome | 790 | |
| chr15:82,809,212–82,810,601 | 39 bp | At TSS Multiome | 808 | |
| chr15:82,849,476–82,850,366 | 40.2 kb | Distal (>10kb) Multiome | 450 | |
| chr15:82,910,611–82,911,202 | 101.4 kb | Distal (>10kb) Multiome | 35 | |
| chr15:82,952,161–82,953,316 | 143.1 kb | Distal (>10kb) Multiome | 430 | |
| chr15:82,985,830–82,986,497 | 176.5 kb | Distal (>10kb) Multiome | 853 | |
| chr15:83,010,925–83,012,341 | 202.0 kb | Distal (>10kb) Multiome | 964 | |
| chr15:83,066,587–83,067,782 | 257.6 kb | Distal (>10kb) Multiome | 877 | |
| chr15:83,106,916–83,108,096 | 297.7 kb | Distal (>10kb) Multiome | 392 |
Genomic view of the WHAMM locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.