Predicted to enable enzyme inhibitor activity; histone binding activity; and histone deacetylase binding activity. Predicted to be involved in negative regulation of fatty acid biosynthetic process. Predicted to act upstream of or within several processes, including cellular response to insulin stimulus; glucose metabolic process; and negative regulation of transcription by RNA polymerase II. Predicted to be located in nucleoplasm. Predicted to be part of Cul4-RING E3 ubiquitin ligase complex. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for WDTC1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = WDTC1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of WDTC1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:26,959,908–26,960,855 | 274.2 kb | Distal (>10kb) Multiome | 607 | |
| chr1:26,992,986–26,995,593 | 241.0 kb | Distal (>10kb) Multiome | 854 | |
| chr1:26,997,489–26,998,161 | 236.8 kb | Distal (>10kb) Multiome | 550 | |
| chr1:27,010,686–27,011,820 | 223.4 kb | Distal (>10kb) Multiome | 379 | |
| chr1:27,012,151–27,013,639 | 221.6 kb | Distal (>10kb) Multiome | 712 | |
| chr1:27,031,351–27,031,956 | 202.9 kb | Distal (>10kb) Multiome | 260 | |
| chr1:27,102,589–27,103,140 | 131.7 kb | Distal (>10kb) Multiome | 263 | |
| chr1:27,154,381–27,155,711 | 79.5 kb | Distal (>10kb) Multiome | 1038 | |
| chr1:27,233,894–27,235,362 | 138 bp | At TSS Multiome | 807 | |
| chr1:27,321,904–27,322,688 | 87.5 kb | Distal (>10kb) Multiome | 1013 | |
| chr1:27,349,161–27,350,366 | 115.2 kb | Distal (>10kb) Multiome | 573 | |
| chr1:27,350,548–27,351,814 | 116.7 kb | Distal (>10kb) Multiome | 387 | |
| chr1:27,357,379–27,358,028 | 123.0 kb | Distal (>10kb) Multiome | 449 | |
| chr1:27,360,338–27,361,256 | 125.9 kb | Distal (>10kb) Multiome | 170 | |
| chr1:27,365,152–27,367,350 | 132.2 kb | Distal (>10kb) Multiome | 748 | |
| chr1:27,382,910–27,383,795 | 148.7 kb | Distal (>10kb) Multiome | 234 | |
| chr1:27,391,473–27,393,056 | 157.9 kb | Distal (>10kb) Multiome | 700 | |
| chr1:27,489,673–27,490,714 | 255.6 kb | Distal (>10kb) Multiome | 978 | |
| chr1:27,526,947–27,528,904 | 292.8 kb | Distal (>10kb) Multiome | 804 |
Genomic view of the WDTC1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.