Predicted to enable ubiquitin-protein transferase activity. Predicted to be involved in protein ubiquitination. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for WDSUB1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = WDSUB1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of WDSUB1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:158,994,876–158,995,952 | 291.2 kb | Distal (>10kb) Multiome | 432 | |
| chr2:159,030,773–159,031,420 | 255.5 kb | Distal (>10kb) Multiome | 313 | |
| chr2:159,049,902–159,050,747 | 236.2 kb | Distal (>10kb) Multiome | 159 | |
| chr2:159,064,425–159,065,288 | 221.9 kb | Distal (>10kb) Multiome | 323 | |
| chr2:159,211,403–159,212,003 | 75.0 kb | Distal (>10kb) Multiome | 180 | |
| chr2:159,285,534–159,287,418 | 116 bp | At TSS Multiome | 1065 |
Genomic view of the WDSUB1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.