Enables enzyme binding activity. Involved in DNA damage response. Located in heterochromatin; nucleus; and site of DNA damage. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for WDR76. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = WDR76 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of WDR76, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:43,746,005–43,746,833 | 80.6 kb | Distal (>10kb) Multiome | 588 | |
| chr15:43,776,241–43,777,647 | 49.8 kb | Distal (>10kb) Multiome | 761 | |
| chr15:43,791,747–43,792,642 | 34.8 kb | Distal (>10kb) Multiome | 821 | |
| chr15:43,824,641–43,824,874 | 2.1 kb | Proximal (<10kb) | 721 | |
| chr15:43,826,833–43,827,061 | at TSS | At TSS | 550 |
Genomic view of the WDR76 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.