This gene encodes a protein with eight WD-40 repeats. Mutations in this gene have been associated with amelogenesis imperfecta hypomaturation type 2A3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013]
Transcription factors with Perturb-seq knockdown data for WDR72. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = WDR72 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of WDR72, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:52,789,439–52,791,791 | 969.2 kb | Distal (>10kb) Multiome HiCAR | 633 | |
| chr15:52,804,516–52,806,560 | 953.9 kb | Distal (>10kb) Multiome HiCAR | 322 | |
| chr15:53,758,987–53,760,031 | at TSS | At TSS Multiome | 192 | |
| chr15:53,810,311–53,811,031 | 51.0 kb | Distal (>10kb) Multiome | 127 | |
| chr15:53,918,170–53,918,968 | 158.8 kb | Distal (>10kb) Multiome | 185 |
Genomic view of the WDR72 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.