This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. The encoded protein interacts with serine/threonine kinase 11, and is implicated in cell growth arrest. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2016]
Transcription factors with Perturb-seq knockdown data for WDR6. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = WDR6 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of WDR6, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:48,661,275–48,664,636 | 343.4 kb | Distal (>10kb) Multiome HiCAR | 1248 | |
| chr3:48,716,958–48,717,863 | 290.1 kb | Distal (>10kb) Multiome | 634 | |
| chr3:48,847,059–48,848,224 | 159.6 kb | Distal (>10kb) Multiome | 772 | |
| chr3:48,898,423–48,899,110 | 108.5 kb | Distal (>10kb) Multiome | 739 | |
| chr3:48,918,234–48,919,609 | 88.6 kb | Distal (>10kb) Multiome | 877 | |
| chr3:48,989,537–48,991,069 | 17.3 kb | Distal (>10kb) Multiome | 552 | |
| chr3:49,003,975–49,004,995 | 2.9 kb | Proximal (<10kb) Multiome | 209 | |
| chr3:49,006,738–49,008,496 | 514 bp | At TSS Multiome | 955 | |
| chr3:49,013,965–49,014,376 | 6.6 kb | Proximal (<10kb) | 210 | |
| chr3:49,017,789–49,018,870 | 11.1 kb | Distal (>10kb) Multiome HiCAR | 780 | |
| chr3:49,020,066–49,022,597 | 14.4 kb | Distal (>10kb) Multiome | 1064 | |
| chr3:49,028,856–49,029,800 | 22.0 kb | Distal (>10kb) Multiome | 974 | |
| chr3:49,093,005–49,094,956 | 86.9 kb | Distal (>10kb) Multiome | 944 | |
| chr3:49,104,279–49,105,309 | 97.4 kb | Distal (>10kb) Multiome | 712 | |
| chr3:49,120,575–49,121,282 | 113.5 kb | Distal (>10kb) Multiome | 765 | |
| chr3:49,132,603–49,133,965 | 126.3 kb | Distal (>10kb) Multiome | 652 | |
| chr3:49,166,057–49,166,586 | 158.9 kb | Distal (>10kb) Multiome | 622 | |
| chr3:49,170,896–49,171,950 | 164.0 kb | Distal (>10kb) Multiome | 781 | |
| chr3:49,276,912–49,277,398 | 269.7 kb | Distal (>10kb) Multiome | 291 |
Genomic view of the WDR6 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.