Predicted to act upstream of or within several processes, including detection of hot stimulus involved in thermoception; neuronal stem cell population maintenance; and telencephalon development. Predicted to be located in several cellular components, including growth cone; microtubule; and neuronal cell body. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for WDR47. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = WDR47 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of WDR47, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:108,746,190–108,747,539 | 295.4 kb | Distal (>10kb) Multiome | 1013 | |
| chr1:108,828,188–108,828,798 | 213.7 kb | Distal (>10kb) Multiome | 359 | |
| chr1:108,842,454–108,843,162 | 199.4 kb | Distal (>10kb) Multiome | 142 | |
| chr1:108,845,269–108,845,935 | 196.5 kb | Distal (>10kb) Multiome | 30 | |
| chr1:108,861,842–108,862,840 | 179.7 kb | Distal (>10kb) Multiome | 54 | |
| chr1:108,876,465–108,877,492 | 165.1 kb | Distal (>10kb) Multiome | 823 | |
| chr1:108,963,024–108,963,620 | 78.7 kb | Distal (>10kb) Multiome | 906 | |
| chr1:109,041,106–109,042,646 | 46 bp | At TSS Multiome | 792 | |
| chr1:109,075,733–109,076,324 | 34.0 kb | Distal (>10kb) Multiome | 864 | |
| chr1:109,090,360–109,091,274 | 48.7 kb | Distal (>10kb) Multiome | 1016 | |
| chr1:109,099,660–109,100,771 | 58.0 kb | Distal (>10kb) Multiome | 1149 | |
| chr1:109,112,499–109,113,189 | 70.7 kb | Distal (>10kb) Multiome | 536 | |
| chr1:109,113,744–109,114,449 | 72.1 kb | Distal (>10kb) Multiome | 236 | |
| chr1:109,213,499–109,214,619 | 171.8 kb | Distal (>10kb) Multiome | 770 | |
| chr1:109,229,475–109,230,215 | 187.8 kb | Distal (>10kb) Multiome | 221 | |
| chr1:109,240,604–109,241,116 | 198.9 kb | Distal (>10kb) Multiome | 391 | |
| chr1:109,249,055–109,250,364 | 207.4 kb | Distal (>10kb) Multiome | 527 | |
| chr1:109,263,250–109,264,042 | 221.6 kb | Distal (>10kb) Multiome | 767 | |
| chr1:109,282,693–109,283,858 | 241.1 kb | Distal (>10kb) Multiome | 850 | |
| chr1:109,306,995–109,308,024 | 265.5 kb | Distal (>10kb) Multiome | 425 |
Genomic view of the WDR47 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.