Enables GTPase activator activity. Contributes to guanyl-nucleotide exchange factor activity. Involved in regulation of autophagy. Located in cytoplasm. Part of guanyl-nucleotide exchange factor complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for WDR41. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = WDR41 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of WDR41, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:77,210,182–77,211,717 | 282.1 kb | Distal (>10kb) Multiome | 287 | |
| chr5:77,231,266–77,232,033 | 260.8 kb | Distal (>10kb) Multiome | 69 | |
| chr5:77,491,730–77,492,869 | 166 bp | At TSS Multiome | 905 | |
| chr5:77,629,708–77,631,041 | 137.8 kb | Distal (>10kb) Multiome | 548 | |
| chr5:77,638,449–77,639,477 | 146.4 kb | Distal (>10kb) Multiome | 181 | |
| chr5:77,750,907–77,751,280 | 258.7 kb | Distal (>10kb) Multiome | 37 | |
| chr5:77,775,064–77,776,789 | 283.8 kb | Distal (>10kb) Multiome | 867 | |
| chr5:77,781,125–77,781,620 | 288.9 kb | Distal (>10kb) Multiome | 87 |
Genomic view of the WDR41 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.