This gene encodes a WD repeat-containing protein that functions to preserve and regulate the activity of the USP12-UAF1 deubiquitinating enzyme complex. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jun 2011]
Transcription factors with Perturb-seq knockdown data for WDR20. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = WDR20 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of WDR20, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:101,947,631–101,948,934 | 191.7 kb | Distal (>10kb) Multiome | 984 | |
| chr14:101,963,949–101,965,702 | 175.4 kb | Distal (>10kb) Multiome | 798 | |
| chr14:102,046,172–102,046,761 | 93.4 kb | Distal (>10kb) Multiome | 326 | |
| chr14:102,086,286–102,088,835 | 52.7 kb | Distal (>10kb) Multiome | 1052 | |
| chr14:102,097,398–102,098,067 | 42.2 kb | Distal (>10kb) Multiome | 159 | |
| chr14:102,139,026–102,140,960 | 208 bp | At TSS Multiome | 844 | |
| chr14:102,247,845–102,248,746 | 108.5 kb | Distal (>10kb) Multiome | 142 | |
| chr14:102,304,511–102,305,687 | 165.3 kb | Distal (>10kb) Multiome | 568 | |
| chr14:102,314,028–102,314,685 | 174.5 kb | Distal (>10kb) Multiome | 720 | |
| chr14:102,316,590–102,317,741 | 177.2 kb | Distal (>10kb) Multiome | 885 | |
| chr14:102,319,368–102,320,458 | 179.8 kb | Distal (>10kb) Multiome | 675 | |
| chr14:102,362,620–102,363,583 | 223.1 kb | Distal (>10kb) Multiome | 705 |
Genomic view of the WDR20 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.