This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for WDR18. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = WDR18 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of WDR18, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:703,387–704,718 | 280.3 kb | Distal (>10kb) Multiome | 586 | |
| chr19:708,425–709,293 | 275.5 kb | Distal (>10kb) Multiome | 317 | |
| chr19:796,668–798,362 | 187.1 kb | Distal (>10kb) Multiome | 956 | |
| chr19:821,294–822,728 | 162.2 kb | Distal (>10kb) Multiome | 254 | |
| chr19:861,664–863,223 | 122.1 kb | Distal (>10kb) Multiome | 530 | |
| chr19:892,703–893,746 | 91.1 kb | Distal (>10kb) Multiome | 715 | |
| chr19:917,038–918,169 | 66.5 kb | Distal (>10kb) Multiome HiCAR | 711 | |
| chr19:924,743–926,242 | 58.6 kb | Distal (>10kb) Multiome HiCAR | 796 | |
| chr19:927,058–927,629 | 57.0 kb | Distal (>10kb) Multiome HiCAR | 362 | |
| chr19:982,565–983,215 | 1.5 kb | Proximal (<10kb) Multiome | 590 | |
| chr19:984,046–985,154 | 158 bp | At TSS Multiome | 829 | |
| chr19:991,298–991,443 | 7.0 kb | Proximal (<10kb) | 100 | |
| chr19:991,838–992,214 | 7.5 kb | Proximal (<10kb) | 186 | |
| chr19:1,000,142–1,000,881 | 16.0 kb | Distal (>10kb) Multiome | 399 | |
| chr19:1,020,611–1,022,069 | 37.1 kb | Distal (>10kb) Multiome | 1017 | |
| chr19:1,026,155–1,026,856 | 42.2 kb | Distal (>10kb) Multiome | 598 | |
| chr19:1,027,770–1,028,926 | 44.2 kb | Distal (>10kb) Multiome | 584 | |
| chr19:1,039,648–1,040,400 | 55.6 kb | Distal (>10kb) Multiome | 684 | |
| chr19:1,040,481–1,041,402 | 56.8 kb | Distal (>10kb) Multiome | 556 | |
| chr19:1,044,758–1,045,598 | 61.0 kb | Distal (>10kb) Multiome | 402 | |
| chr19:1,061,840–1,062,923 | 78.2 kb | Distal (>10kb) Multiome | 204 | |
| chr19:1,063,045–1,065,722 | 80.5 kb | Distal (>10kb) Multiome | 681 | |
| chr19:1,066,682–1,067,587 | 82.9 kb | Distal (>10kb) Multiome | 489 | |
| chr19:1,071,107–1,071,721 | 86.8 kb | Distal (>10kb) Multiome | 178 | |
| chr19:1,081,317–1,083,172 | 98.1 kb | Distal (>10kb) Multiome | 484 | |
| chr19:1,094,985–1,095,654 | 111.1 kb | Distal (>10kb) Multiome | 671 | |
| chr19:1,103,487–1,105,654 | 119.7 kb | Distal (>10kb) Multiome | 849 | |
| chr19:1,112,029–1,112,884 | 128.0 kb | Distal (>10kb) Multiome | 294 | |
| chr19:1,113,014–1,114,139 | 129.2 kb | Distal (>10kb) Multiome | 690 | |
| chr19:1,122,934–1,123,720 | 138.9 kb | Distal (>10kb) Multiome | 231 | |
| chr19:1,173,441–1,174,438 | 189.9 kb | Distal (>10kb) Multiome | 682 | |
| chr19:1,194,370–1,194,985 | 210.3 kb | Distal (>10kb) Multiome | 531 | |
| chr19:1,205,175–1,206,374 | 221.3 kb | Distal (>10kb) Multiome | 746 | |
| chr19:1,237,080–1,238,434 | 253.7 kb | Distal (>10kb) Multiome | 430 | |
| chr19:1,239,513–1,242,539 | 257.4 kb | Distal (>10kb) Multiome | 889 | |
| chr19:1,244,253–1,244,857 | 260.2 kb | Distal (>10kb) Multiome | 590 | |
| chr19:1,247,981–1,252,501 | 266.7 kb | Distal (>10kb) Multiome | 1136 | |
| chr19:1,259,185–1,262,955 | 275.0 kb | Distal (>10kb) Multiome | 1070 | |
| chr19:1,265,280–1,270,235 | 284.9 kb | Distal (>10kb) Multiome | 1171 | |
| chr19:1,274,423–1,276,502 | 291.4 kb | Distal (>10kb) Multiome | 967 |
Genomic view of the WDR18 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.