This gene encodes a cytoplasmic WD40 repeat protein. A similar gene in frogs encodes a planar cell polarity protein that plays a critical role in collective cell movement and ciliogenesis by mediating septin localization. Mutations in this gene are associated with Bardet-Biedl syndrome 15 and may also play a role in Meckel-Gruber syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]
Transcription factors with Perturb-seq knockdown data for WDPCP. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = WDPCP upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of WDPCP, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:63,399,198–63,399,769 | 188.8 kb | Distal (>10kb) Multiome | 160 | |
| chr2:63,572,050–63,572,620 | 16.0 kb | Distal (>10kb) Multiome | 43 | |
| chr2:63,587,861–63,589,431 | 479 bp | At TSS Multiome | 1009 | |
| chr2:63,600,759–63,601,822 | 13.1 kb | Distal (>10kb) Multiome | 194 | |
| chr2:63,746,437–63,747,016 | 158.5 kb | Distal (>10kb) Multiome | 145 | |
| chr2:63,840,151–63,842,662 | 253.5 kb | Distal (>10kb) Multiome | 1134 |
Genomic view of the WDPCP locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.