This gene encodes a protein that contains two WD domains and an FYVE zinc finger region. The function of this gene is unknown. An alternatively spliced transcript variant of this gene may exist. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for WDFY2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = WDFY2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of WDFY2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr13:51,303,027–51,303,676 | 281.2 kb | Distal (>10kb) Multiome | 130 | |
| chr13:51,451,249–51,454,202 | 132.7 kb | Distal (>10kb) Multiome | 1037 | |
| chr13:51,583,370–51,585,461 | 294 bp | At TSS Multiome | 1008 | |
| chr13:51,795,081–51,795,749 | 211.0 kb | Distal (>10kb) Multiome HiCAR | 50 | |
| chr13:51,803,129–51,804,466 | 219.5 kb | Distal (>10kb) Multiome | 844 |
Genomic view of the WDFY2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.