Predicted to enable ubiquitin protein ligase binding activity. Predicted to be involved in CXCL12-activated CXCR4 signaling pathway. Predicted to act upstream of or within hemopoiesis and positive regulation of protein ubiquitination. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for WBP1L. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = WBP1L upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of WBP1L, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:102,449,444–102,451,250 | 294.2 kb | Distal (>10kb) Multiome | 810 | |
| chr10:102,454,792–102,455,588 | 288.9 kb | Distal (>10kb) Multiome | 159 | |
| chr10:102,460,805–102,462,064 | 282.6 kb | Distal (>10kb) Multiome | 665 | |
| chr10:102,501,628–102,503,235 | 241.8 kb | Distal (>10kb) Multiome | 738 | |
| chr10:102,503,432–102,504,897 | 240.0 kb | Distal (>10kb) Multiome | 684 | |
| chr10:102,641,824–102,646,130 | 98.9 kb | Distal (>10kb) Multiome | 1123 | |
| chr10:102,678,809–102,679,295 | 64.9 kb | Distal (>10kb) Multiome | 476 | |
| chr10:102,713,669–102,715,337 | 29.6 kb | Distal (>10kb) Multiome | 895 | |
| chr10:102,735,230–102,735,520 | 8.5 kb | Proximal (<10kb) | 125 | |
| chr10:102,743,388–102,744,547 | 161 bp | At TSS Multiome | 777 | |
| chr10:102,776,775–102,777,340 | 33.0 kb | Distal (>10kb) Multiome | 419 | |
| chr10:102,853,920–102,854,718 | 110.4 kb | Distal (>10kb) Multiome | 859 | |
| chr10:102,869,308–102,870,223 | 125.6 kb | Distal (>10kb) Multiome | 509 | |
| chr10:102,916,941–102,919,907 | 174.2 kb | Distal (>10kb) Multiome | 984 |
Genomic view of the WBP1L locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.