This gene encodes a nuclear protein, which colocalizes with mRNA splicing factors and intermediate filament-containing perinuclear networks. This protein has 95% amino acid sequence identity to the mouse Wbp11 protein. It contains two proline-rich regions that bind to the WW domain of Npw38, a nuclear protein, and thus this protein is also called Npw38-binding protein NpwBP. The Npw38-NpwBP complex may function as a component of an mRNA factory in the nucleus. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for WBP11. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = WBP11 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of WBP11, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:14,567,263–14,568,383 | 235.7 kb | Distal (>10kb) Multiome | 366 | |
| chr12:14,710,018–14,711,213 | 92.8 kb | Distal (>10kb) Multiome | 148 | |
| chr12:14,768,991–14,772,177 | 33.6 kb | Distal (>10kb) Multiome HiCAR | 1151 | |
| chr12:14,773,514–14,775,433 | 29.2 kb | Distal (>10kb) Multiome HiCAR | 550 | |
| chr12:14,802,974–14,804,269 | 107 bp | At TSS Multiome | 702 | |
| chr12:14,811,214–14,811,383 | 7.7 kb | Proximal (<10kb) | 77 |
Genomic view of the WBP11 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.