Enables phosphatidylinositol phosphate binding activity; phosphatidylinositol-3,4-bisphosphate binding activity; and retromer complex binding activity. Involved in several processes, including endosomal transport; negative regulation of barbed-end actin filament capping; and protein localization to endosome. Located in cytosol; early endosome; and nucleolus. Part of WASH complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for WASHC2C. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = WASHC2C upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of WASHC2C, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:45,249,912–45,250,539 | 477.3 kb | Distal (>10kb) Multiome HiCAR | 197 | |
| chr10:45,594,255–45,595,274 | 132.5 kb | Distal (>10kb) Multiome | 982 | |
| chr10:45,672,004–45,673,546 | 54.5 kb | Distal (>10kb) Multiome | 871 | |
| chr10:45,726,765–45,727,627 | 56 bp | At TSS Multiome | 520 | |
| chr10:46,023,121–46,023,829 | 296.2 kb | Distal (>10kb) Multiome | 900 |
Genomic view of the WASHC2C locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.