Located in nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for VWA5A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = VWA5A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of VWA5A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:123,865,333–123,866,263 | 249.9 kb | Distal (>10kb) Multiome | 63 | |
| chr11:123,876,205–123,876,809 | 238.9 kb | Distal (>10kb) Multiome | 11 | |
| chr11:124,068,701–124,070,224 | 46.5 kb | Distal (>10kb) Multiome | 408 | |
| chr11:124,108,191–124,108,421 | 7.0 kb | Proximal (<10kb) | 82 | |
| chr11:124,114,725–124,116,617 | 239 bp | At TSS Multiome | 611 | |
| chr11:124,123,498–124,123,885 | 8.0 kb | Proximal (<10kb) | 92 | |
| chr11:124,170,877–124,171,474 | 55.6 kb | Distal (>10kb) Multiome | 196 | |
| chr11:124,190,119–124,191,140 | 75.1 kb | Distal (>10kb) Multiome | 142 |
Genomic view of the VWA5A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.