This gene encodes a member of the von Willebrand factor A-like domain protein superfamily. The encoded protein is localized to the extracellular matrix and may serve as a structural component in basement membranes or in anchoring structures on scaffolds of collagen VII or fibrillin. This gene has been linked to type 1A diabetes and is a candidate serological marker for colon cancer. [provided by RefSeq, Jan 2013]
Transcription factors with Perturb-seq knockdown data for VWA2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = VWA2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of VWA2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:114,042,897–114,045,651 | 194.1 kb | Distal (>10kb) Multiome | 503 | |
| chr10:114,173,477–114,175,128 | 65.0 kb | Distal (>10kb) Multiome | 842 | |
| chr10:114,234,211–114,234,448 | 4.9 kb | Proximal (<10kb) | 18 | |
| chr10:114,239,111–114,240,320 | 290 bp | At TSS Multiome | 417 | |
| chr10:114,303,821–114,305,401 | 65.5 kb | Distal (>10kb) Multiome | 424 | |
| chr10:114,402,845–114,405,341 | 164.4 kb | Distal (>10kb) Multiome | 410 | |
| chr10:114,526,358–114,527,267 | 287.6 kb | Distal (>10kb) Multiome | 770 |
Genomic view of the VWA2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.