Transcription factors with Perturb-seq knockdown data for VSTM2B-DT. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = VSTM2B-DT upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of VSTM2B-DT, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:29,525,368–29,525,779 | at TSS | At TSS | 133 | |
| chr19:29,525,914–29,526,665 | 170 bp | At TSS | 132 | |
| chr19:29,526,770–29,527,553 | 1.0 kb | Proximal (<10kb) | 188 | |
| chr19:29,528,180–29,529,621 | 2.4 kb | Proximal (<10kb) | 401 | |
| chr19:29,529,766–29,530,718 | 4.0 kb | Proximal (<10kb) | 175 |
Genomic view of the VSTM2B-DT locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.