This gene encodes a protein that is a subunit of the endosomal sorting complex required for transport II (ESCRT-II). This protein complex functions in sorting of ubiquitinated membrane proteins during endocytosis. A similar protein complex in rat is associated with RNA polymerase elongation factor II. [provided by RefSeq, Aug 2013]
Transcription factors with Perturb-seq knockdown data for VPS36. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = VPS36 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of VPS36, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr13:52,159,155–52,160,117 | 291.1 kb | Distal (>10kb) Multiome HiCAR | 831 | |
| chr13:52,194,155–52,194,839 | 256.2 kb | Distal (>10kb) Multiome HiCAR | 888 | |
| chr13:52,195,279–52,195,948 | 254.9 kb | Distal (>10kb) Multiome | 267 | |
| chr13:52,449,904–52,451,090 | 16 bp | At TSS Multiome | 972 | |
| chr13:52,454,948–52,456,258 | 4.8 kb | Proximal (<10kb) Multiome | 791 | |
| chr13:52,599,686–52,600,643 | 149.7 kb | Distal (>10kb) Multiome | 545 | |
| chr13:52,617,038–52,617,928 | 166.8 kb | Distal (>10kb) Multiome | 723 | |
| chr13:52,651,967–52,653,338 | 202.0 kb | Distal (>10kb) Multiome | 966 | |
| chr13:52,738,655–52,740,130 | 288.4 kb | Distal (>10kb) Multiome | 284 |
Genomic view of the VPS36 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.