Predicted to be involved in intracellular protein transport and retrograde transport, endosome to Golgi. Predicted to act upstream of or within cellular response to type II interferon. Predicted to be located in early endosome and late endosome. Predicted to be part of retromer complex. Predicted to be active in glutamatergic synapse; postsynaptic early endosome; and postsynaptic recycling endosome. [provided by Alliance of Genome Resources, Apr 2025]
Transcription factors with Perturb-seq knockdown data for VPS26B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = VPS26B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of VPS26B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:133,947,207–133,947,600 | 277.3 kb | Distal (>10kb) Multiome | 204 | |
| chr11:133,951,064–133,952,093 | 273.1 kb | Distal (>10kb) Multiome | 268 | |
| chr11:133,955,545–133,957,834 | 267.6 kb | Distal (>10kb) Multiome | 423 | |
| chr11:134,033,701–134,034,640 | 190.5 kb | Distal (>10kb) Multiome | 251 | |
| chr11:134,036,538–134,037,918 | 187.4 kb | Distal (>10kb) Multiome | 381 | |
| chr11:134,068,849–134,069,824 | 155.6 kb | Distal (>10kb) Multiome | 407 | |
| chr11:134,223,679–134,225,624 | 65 bp | At TSS Multiome | 944 | |
| chr11:134,252,809–134,254,050 | 28.8 kb | Distal (>10kb) Multiome | 758 | |
| chr11:134,272,860–134,273,509 | 48.4 kb | Distal (>10kb) Multiome | 183 | |
| chr11:134,275,655–134,277,823 | 51.8 kb | Distal (>10kb) Multiome | 418 | |
| chr11:134,331,384–134,332,745 | 107.2 kb | Distal (>10kb) Multiome | 483 | |
| chr11:134,360,067–134,360,637 | 135.8 kb | Distal (>10kb) Multiome | 397 | |
| chr11:134,411,283–134,413,029 | 187.5 kb | Distal (>10kb) Multiome | 258 |
Genomic view of the VPS26B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.