Involved in mitochondrion organization and negative regulation of type 2 mitophagy. Located in several cellular components, including late endosome; lipid droplet; and mitochondrial outer membrane. Implicated in Parkinson's disease 23. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for VPS13C. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = VPS13C upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of VPS13C, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:62,059,766–62,061,089 | 43 bp | At TSS Multiome | 902 | |
| chr15:62,066,677–62,067,271 | 6.5 kb | Proximal (<10kb) Multiome | 486 | |
| chr15:62,067,533–62,068,712 | 7.8 kb | Proximal (<10kb) Multiome | 392 | |
| chr15:62,083,542–62,084,428 | 23.5 kb | Distal (>10kb) Multiome | 54 | |
| chr15:62,163,863–62,165,574 | 104.8 kb | Distal (>10kb) Multiome | 349 | |
| chr15:62,209,095–62,210,128 | 149.1 kb | Distal (>10kb) Multiome | 86 |
Genomic view of the VPS13C locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.