This gene encodes a transmembrane protein that plays a key regulatory role in the process of autophagy. The ectopic overexpression of the encoded protein in cultured cells triggers autophagy even under nutrient-rich conditions. This gene is overexpressed in pancreatitis affected acinar cells where the encoded protein mediates sequestration and degradation of potentially deleterious activated zymogen granules in a process termed, zymophagy. [provided by RefSeq, Jul 2016]
Transcription factors with Perturb-seq knockdown data for VMP1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = VMP1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of VMP1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:57,874,428–57,875,544 | 1832.8 kb | Distal (>10kb) Multiome HiCAR | 639 | |
| chr17:59,418,775–59,419,543 | 288.6 kb | Distal (>10kb) Multiome | 216 | |
| chr17:59,423,282–59,424,320 | 283.7 kb | Distal (>10kb) Multiome | 316 | |
| chr17:59,565,384–59,566,262 | 142.0 kb | Distal (>10kb) Multiome | 1120 | |
| chr17:59,619,053–59,620,313 | 88.0 kb | Distal (>10kb) Multiome | 1183 | |
| chr17:59,707,078–59,708,143 | 73 bp | At TSS Multiome | 963 | |
| chr17:59,837,406–59,838,036 | 130.1 kb | Distal (>10kb) Multiome | 865 | |
| chr17:59,892,295–59,893,854 | 185.4 kb | Distal (>10kb) Multiome | 992 | |
| chr17:59,964,460–59,965,228 | 257.2 kb | Distal (>10kb) Multiome | 834 | |
| chr17:60,037,145–60,037,598 | 329.7 kb | Distal (>10kb) Multiome HiCAR | 592 | |
| chr17:60,078,377–60,079,189 | 371.2 kb | Distal (>10kb) Multiome | 765 | |
| chr17:60,135,208–60,135,905 | 428.0 kb | Distal (>10kb) Multiome | 832 |
Genomic view of the VMP1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.