This gene encodes a protein with a transcriptional enhancer factor 1 (TEF-1) interaction domain. The encoded protein may act as a co-factor of TEF-1 regulated gene expression during skeletal muscle development. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Jul 2012]
Transcription factors with Perturb-seq knockdown data for VGLL2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = VGLL2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of VGLL2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:117,264,496–117,266,315 | at TSS | At TSS | 442 | |
| chr6:117,266,416–117,266,536 | 859 bp | At TSS | 23 | |
| chr6:117,268,014–117,268,801 | 2.5 kb | Proximal (<10kb) | 92 | |
| chr6:117,270,051–117,271,235 | 4.5 kb | Proximal (<10kb) | 235 | |
| chr6:117,272,033–117,272,600 | 6.5 kb | Proximal (<10kb) | 68 |
Genomic view of the VGLL2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.