This gene encodes a transmembrane protein which has been localized to adherens junctions and shown to bind to myosin VIIA. Examination of expression of this gene in gastric cancer tissues have shown that expression is decreased which appears to be related to hypermethylation of the promoter. Expression of this gene may also be inhibited by binding of a specific microRNA to a target sequence in the 3' UTR of the transcripts. A pseudogene of this gene is located on the X chromosome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2011]
Transcription factors with Perturb-seq knockdown data for VEZT. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = VEZT upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of VEZT, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:95,003,172–95,003,905 | 214.1 kb | Distal (>10kb) Multiome | 875 | |
| chr12:95,072,721–95,073,838 | 144.2 kb | Distal (>10kb) Multiome | 927 | |
| chr12:95,129,410–95,130,455 | 87.7 kb | Distal (>10kb) Multiome | 158 | |
| chr12:95,216,693–95,218,575 | 201 bp | At TSS Multiome | 1001 | |
| chr12:95,442,539–95,444,040 | 225.8 kb | Distal (>10kb) Multiome | 107 | |
| chr12:95,446,296–95,447,252 | 228.9 kb | Distal (>10kb) Multiome | 289 | |
| chr12:95,473,495–95,474,647 | 256.2 kb | Distal (>10kb) Multiome | 953 |
Genomic view of the VEZT locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.