VCPIP1
valosin containing protein interacting protein 1 | DUBA3, FLJ23132, KIAA1850, VCIP135

Enables cysteine-type deubiquitinase activity. Involved in protein deubiquitination; protein-DNA covalent cross-linking repair; and regulation of protein localization to chromatin. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Member of: DE-5
Biological processes 29 terms
DNA damage response (GO:0006974)Golgi organization (GO:0007030)Golgi reassembly (GO:0090168)Golgi reassembly (GO:0090168)Golgi stack (GO:0005795)catalytic activity (GO:0003824)cysteine-type deubiquitinase activity (GO:0004843)cysteine-type deubiquitinase activity (GO:0004843)cysteine-type deubiquitinase activity (GO:0004843)cysteine-type deubiquitinase activity (GO:0004843)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytosol (GO:0005829)endoplasmic reticulum (GO:0005783)endoplasmic reticulum lumen (GO:0005788)endoplasmic reticulum membrane fusion (GO:0016320)endoplasmic reticulum membrane fusion (GO:0016320)nucleus (GO:0005634)nucleus (GO:0005634)protein K11-linked deubiquitination (GO:0035871)protein K48-linked deubiquitination (GO:0071108)protein binding (GO:0005515)protein deubiquitination (GO:0016579)protein ubiquitination (GO:0016567)protein ubiquitination (GO:0016567)protein unfolding (GO:0043335)protein-DNA covalent cross-linking repair (GO:0106300)protein-DNA covalent cross-linking repair (GO:0106300)regulation of protein localization to chromatin (GO:1905634)
Expression (TPM)
VCPIP1 — as a Regulated Gene

TFs regulating VCPIP1 0 TFs

Transcription factors with Perturb-seq knockdown data for VCPIP1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = VCPIP1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to VCPIP1

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of VCPIP1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr8:66,428,113–66,430,401 238.4 kb Distal (>10kb) Multiome 921
chr8:66,431,895–66,432,840 234.7 kb Distal (>10kb) Multiome 609
chr8:66,438,980–66,439,800 228.0 kb Distal (>10kb) Multiome 484
chr8:66,512,582–66,513,139 154.4 kb Distal (>10kb) Multiome 239
chr8:66,612,352–66,614,219 53.9 kb Distal (>10kb) Multiome 862
chr8:66,666,261–66,667,884 120 bp At TSS Multiome 889
chr8:66,712,294–66,713,281 45.5 kb Distal (>10kb) Multiome 648
chr8:66,774,026–66,775,860 107.9 kb Distal (>10kb) Multiome 957
chr8:66,870,495–66,871,236 203.6 kb Distal (>10kb) Multiome 352
chr8:66,924,535–66,926,136 258.4 kb Distal (>10kb) Multiome 998
chr8:66,961,090–66,963,532 295.4 kb Distal (>10kb) Multiome 438
chr8:67,028,419–67,029,071 361.4 kb Distal (>10kb) Multiome HiCAR 488

Genome Browser

Genomic view of the VCPIP1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr8:66,418,113 – 67,039,071
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
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