Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. This gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Because of its high homology to other known VAMPs, its broad tissue distribution, and its subcellular localization, the protein encoded by this gene was shown to be the human equivalent of the rodent cellubrevin. In platelets the protein resides on a compartment that is not mobilized to the plasma membrane on calcium or thrombin stimulation. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for VAMP3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = VAMP3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of VAMP3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:7,550,192–7,550,887 | 220.7 kb | Distal (>10kb) Multiome | 119 | |
| chr1:7,667,425–7,668,031 | 103.6 kb | Distal (>10kb) Multiome HiCAR | 391 | |
| chr1:7,669,374–7,669,989 | 101.6 kb | Distal (>10kb) Multiome HiCAR | 285 | |
| chr1:7,680,111–7,680,720 | 90.8 kb | Distal (>10kb) Multiome | 466 | |
| chr1:7,703,734–7,704,990 | 66.6 kb | Distal (>10kb) Multiome | 419 | |
| chr1:7,770,840–7,771,872 | 33 bp | At TSS Multiome | 711 | |
| chr1:7,783,377–7,785,071 | 12.6 kb | Distal (>10kb) Multiome | 618 | |
| chr1:7,885,362–7,886,254 | 114.4 kb | Distal (>10kb) Multiome | 196 | |
| chr1:7,942,207–7,942,705 | 171.2 kb | Distal (>10kb) Multiome | 315 | |
| chr1:7,953,925–7,954,593 | 182.9 kb | Distal (>10kb) Multiome | 708 | |
| chr1:7,961,111–7,962,145 | 190.3 kb | Distal (>10kb) Multiome | 1012 | |
| chr1:8,004,118–8,005,226 | 233.4 kb | Distal (>10kb) Multiome | 617 | |
| chr1:8,025,593–8,027,129 | 255.1 kb | Distal (>10kb) Multiome | 938 |
Genomic view of the VAMP3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.