Enables RNA binding activity. Involved in ribosomal small subunit biogenesis. Located in nucleolus. Part of small-subunit processome. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for UTP3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = UTP3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of UTP3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:70,474,006–70,475,095 | 214.0 kb | Distal (>10kb) Multiome | 187 | |
| chr4:70,687,549–70,689,032 | 219 bp | At TSS Multiome | 1053 | |
| chr4:70,703,846–70,706,278 | 16.2 kb | Distal (>10kb) Multiome | 934 | |
| chr4:70,836,603–70,837,949 | 148.6 kb | Distal (>10kb) Multiome | 136 | |
| chr4:70,838,760–70,840,084 | 151.4 kb | Distal (>10kb) Multiome | 828 | |
| chr4:70,901,672–70,903,467 | 213.8 kb | Distal (>10kb) Multiome | 915 |
Genomic view of the UTP3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.