Enables RNA binding activity. Involved in several processes, including protein catabolic process; protein destabilization; and protein localization to nucleolus. Located in nucleolus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for UTP25. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = UTP25 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of UTP25, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:209,565,881–209,566,600 | 261.7 kb | Distal (>10kb) Multiome | 193 | |
| chr1:209,627,346–209,628,178 | 200.2 kb | Distal (>10kb) Multiome | 368 | |
| chr1:209,747,459–209,748,502 | 80.1 kb | Distal (>10kb) Multiome | 723 | |
| chr1:209,784,214–209,785,171 | 43.4 kb | Distal (>10kb) Multiome | 859 | |
| chr1:209,805,245–209,806,661 | 21.8 kb | Distal (>10kb) Multiome | 472 | |
| chr1:209,823,176–209,823,362 | 4.6 kb | Proximal (<10kb) | 124 | |
| chr1:209,827,579–209,828,429 | 17 bp | At TSS Multiome | 833 | |
| chr1:209,888,562–209,889,538 | 60.9 kb | Distal (>10kb) Multiome | 75 | |
| chr1:209,937,461–209,938,825 | 110.1 kb | Distal (>10kb) Multiome | 555 | |
| chr1:210,291,920–210,292,942 | 464.5 kb | Distal (>10kb) Multiome HiCAR | 518 |
Genomic view of the UTP25 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.