The protein encoded by this gene is a leucine zipper-containing transcriptional coactivator that may link the upstream activator ATF2 with the basal transcription complex. The encoded protein is closely associated with chromatin and is required for the proper differentiation of embryonic carcinoma and embryonic stem cells. Found nearly exclusively in pluripotent cells, this protein can also serve as a transcriptional repressor. [provided by RefSeq, Nov 2015]
Transcription factors with Perturb-seq knockdown data for UTF1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = UTF1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of UTF1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:132,961,992–132,962,618 | 267.9 kb | Distal (>10kb) Multiome | 155 | |
| chr10:133,143,227–133,144,444 | 86.0 kb | Distal (>10kb) Multiome | 346 | |
| chr10:133,159,602–133,160,521 | 70.0 kb | Distal (>10kb) Multiome | 198 | |
| chr10:133,229,278–133,231,486 | 83 bp | At TSS Multiome | 253 | |
| chr10:133,231,897–133,232,673 | 2.1 kb | Proximal (<10kb) Multiome | 75 | |
| chr10:133,235,225–133,235,826 | 5.5 kb | Proximal (<10kb) Multiome | 122 | |
| chr10:133,236,052–133,238,686 | 7.5 kb | Proximal (<10kb) Multiome | 361 | |
| chr10:133,247,041–133,247,539 | 17.0 kb | Distal (>10kb) Multiome HiCAR | 168 | |
| chr10:133,257,420–133,258,249 | 27.6 kb | Distal (>10kb) Multiome | 384 | |
| chr10:133,261,265–133,262,426 | 31.8 kb | Distal (>10kb) Multiome | 421 | |
| chr10:133,276,420–133,277,460 | 46.7 kb | Distal (>10kb) Multiome | 216 | |
| chr10:133,307,807–133,309,623 | 79.0 kb | Distal (>10kb) Multiome | 785 | |
| chr10:133,318,523–133,319,017 | 88.6 kb | Distal (>10kb) Multiome | 567 | |
| chr10:133,324,203–133,325,065 | 94.3 kb | Distal (>10kb) Multiome | 243 | |
| chr10:133,329,452–133,330,224 | 99.7 kb | Distal (>10kb) Multiome | 471 | |
| chr10:133,357,077–133,358,582 | 127.7 kb | Distal (>10kb) Multiome | 649 | |
| chr10:133,373,095–133,373,842 | 143.2 kb | Distal (>10kb) Multiome | 589 | |
| chr10:133,377,993–133,380,099 | 149.1 kb | Distal (>10kb) Multiome | 714 | |
| chr10:133,393,908–133,394,705 | 164.0 kb | Distal (>10kb) Multiome | 959 |
Genomic view of the UTF1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.