Uronyl 2-sulfotransferase transfers sulfate to the 2-position of uronyl residues, such as iduronyl residues in dermatan sulfate and glucuronyl residues in chondroitin sulfate (Kobayashi et al., 1999 [PubMed 10187838]).[supplied by OMIM, Mar 2008]
Transcription factors with Perturb-seq knockdown data for UST. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = UST upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of UST, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:148,559,643–148,560,385 | 187.0 kb | Distal (>10kb) Multiome | 610 | |
| chr6:148,578,251–148,578,701 | 168.6 kb | Distal (>10kb) Multiome HiCAR | 348 | |
| chr6:148,599,951–148,600,589 | 146.8 kb | Distal (>10kb) Multiome | 183 | |
| chr6:148,746,009–148,748,373 | 786 bp | At TSS Multiome | 709 | |
| chr6:148,748,449–148,748,805 | 1.4 kb | Proximal (<10kb) | 170 | |
| chr6:148,854,871–148,855,534 | 108.2 kb | Distal (>10kb) Multiome | 97 | |
| chr6:148,972,307–148,972,858 | 225.6 kb | Distal (>10kb) Multiome | 405 | |
| chr6:149,014,075–149,015,197 | 267.8 kb | Distal (>10kb) Multiome HiCAR | 221 |
Genomic view of the UST locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.