Enables SUMO binding activity and deSUMOylase activity. Involved in several processes, including Cajal body organization; protein desumoylation; and snRNA transcription. Located in Cajal body. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for USPL1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = USPL1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of USPL1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr13:30,132,589–30,133,092 | 485.1 kb | Distal (>10kb) Multiome HiCAR | 342 | |
| chr13:30,408,104–30,408,932 | 209.4 kb | Distal (>10kb) Multiome | 692 | |
| chr13:30,421,116–30,422,727 | 195.7 kb | Distal (>10kb) Multiome | 513 | |
| chr13:30,445,442–30,446,304 | 172.1 kb | Distal (>10kb) Multiome | 484 | |
| chr13:30,464,236–30,465,228 | 153.2 kb | Distal (>10kb) Multiome HiCAR | 645 | |
| chr13:30,465,545–30,466,629 | 151.9 kb | Distal (>10kb) Multiome HiCAR | 658 | |
| chr13:30,616,955–30,618,550 | 231 bp | At TSS Multiome | 1201 | |
| chr13:30,673,480–30,674,640 | 56.3 kb | Distal (>10kb) Multiome | 857 | |
| chr13:30,740,081–30,740,925 | 122.6 kb | Distal (>10kb) Multiome | 313 | |
| chr13:30,756,867–30,757,734 | 139.4 kb | Distal (>10kb) Multiome | 123 | |
| chr13:30,802,938–30,803,412 | 185.2 kb | Distal (>10kb) Multiome | 441 | |
| chr13:30,824,398–30,825,229 | 206.9 kb | Distal (>10kb) Multiome | 121 | |
| chr13:30,865,208–30,865,660 | 247.6 kb | Distal (>10kb) Multiome | 441 |
Genomic view of the USPL1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.