Enables cysteine-type deubiquitinase activity. Predicted to be involved in protein deubiquitination; regulation of apoptotic process; and regulation of protein stability. Predicted to be located in nucleoplasm. Predicted to be active in cytosol and nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for USP42. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = USP42 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of USP42, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:5,822,727–5,823,386 | 281.9 kb | Distal (>10kb) Multiome | 650 | |
| chr7:6,008,669–6,009,907 | 95.8 kb | Distal (>10kb) Multiome | 1068 | |
| chr7:6,058,614–6,059,749 | 45.8 kb | Distal (>10kb) Multiome | 916 | |
| chr7:6,081,109–6,081,851 | 23.4 kb | Distal (>10kb) Multiome | 904 | |
| chr7:6,103,982–6,105,662 | 173 bp | At TSS Multiome | 1040 | |
| chr7:6,271,933–6,273,059 | 167.7 kb | Distal (>10kb) Multiome | 582 | |
| chr7:6,348,284–6,349,527 | 244.0 kb | Distal (>10kb) Multiome | 787 | |
| chr7:6,374,107–6,375,074 | 269.4 kb | Distal (>10kb) Multiome | 778 |
Genomic view of the USP42 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.