Protein ubiquitination controls many intracellular processes, including cell cycle progression, transcriptional activation, and signal transduction. This dynamic process, involving ubiquitin conjugating enzymes and deubiquitinating enzymes, adds and removes ubiquitin. Deubiquitinating enzymes are cysteine proteases that specifically cleave ubiquitin from ubiquitin-conjugated protein substrates. This protein is a ubiquitin protein ligase and plays a role in muscle wasting. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2017]
Transcription factors with Perturb-seq knockdown data for USP19. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = USP19 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of USP19, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:48,847,059–48,848,224 | 273.1 kb | Distal (>10kb) Multiome | 772 | |
| chr3:48,898,423–48,899,110 | 222.0 kb | Distal (>10kb) Multiome | 739 | |
| chr3:48,918,234–48,919,609 | 202.1 kb | Distal (>10kb) Multiome | 877 | |
| chr3:48,989,537–48,991,069 | 130.9 kb | Distal (>10kb) Multiome | 552 | |
| chr3:49,003,975–49,004,995 | 116.4 kb | Distal (>10kb) Multiome | 209 | |
| chr3:49,006,738–49,008,496 | 113.0 kb | Distal (>10kb) Multiome | 955 | |
| chr3:49,017,789–49,018,870 | 102.5 kb | Distal (>10kb) Multiome | 780 | |
| chr3:49,020,066–49,022,597 | 99.2 kb | Distal (>10kb) Multiome | 1064 | |
| chr3:49,028,856–49,029,800 | 91.5 kb | Distal (>10kb) Multiome | 974 | |
| chr3:49,093,005–49,094,956 | 26.7 kb | Distal (>10kb) Multiome | 944 | |
| chr3:49,104,279–49,105,309 | 16.2 kb | Distal (>10kb) Multiome | 712 | |
| chr3:49,120,575–49,121,282 | 20 bp | At TSS Multiome | 765 | |
| chr3:49,132,603–49,133,965 | 12.8 kb | Distal (>10kb) Multiome | 652 | |
| chr3:49,166,057–49,166,586 | 45.4 kb | Distal (>10kb) Multiome | 622 | |
| chr3:49,170,896–49,171,950 | 50.4 kb | Distal (>10kb) Multiome | 781 | |
| chr3:49,276,912–49,277,398 | 156.1 kb | Distal (>10kb) Multiome | 291 | |
| chr3:49,339,607–49,340,853 | 219.2 kb | Distal (>10kb) Multiome | 1044 | |
| chr3:49,357,868–49,359,083 | 237.5 kb | Distal (>10kb) Multiome | 908 | |
| chr3:49,411,409–49,412,844 | 291.2 kb | Distal (>10kb) Multiome | 899 |
Genomic view of the USP19 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.