USHBP1

USH1 protein network component harmonin binding protein 1 | AIEBP, FLJ38709, MCC2

Enables PDZ domain binding activity. [provided by Alliance of Genome Resources, Jul 2025]

Member of: DE-5

Biological processes 2 terms

PDZ domain binding (GO:0030165)protein binding (GO:0005515)

Expression (TPM)

TFs regulating USHBP1 0 TFs

Transcription factors with Perturb-seq knockdown data for USHBP1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = USHBP1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to USHBP1

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of USHBP1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr19:17,074,934–17,076,532	189.1 kb	Distal (>10kb) Multiome	890
chr19:17,209,430–17,210,427	54.9 kb	Distal (>10kb) Multiome	245
chr19:17,215,005–17,215,979	49.3 kb	Distal (>10kb) Multiome	897
chr19:17,225,705–17,226,889	38.4 kb	Distal (>10kb) Multiome	870
chr19:17,234,748–17,236,650	28.9 kb	Distal (>10kb) Multiome	612
chr19:17,244,882–17,247,104	18.6 kb	Distal (>10kb) Multiome	862
chr19:17,247,935–17,248,860	16.1 kb	Distal (>10kb) Multiome	588
chr19:17,260,923–17,261,240	3.5 kb	Proximal (<10kb)	503
chr19:17,264,709–17,264,934	at TSS	At TSS	119
chr19:17,266,931–17,267,755	2.5 kb	Proximal (<10kb) Multiome	720
chr19:17,281,537–17,283,120	18.1 kb	Distal (>10kb) Multiome	669
chr19:17,292,242–17,293,049	27.9 kb	Distal (>10kb) Multiome	513
chr19:17,302,721–17,303,771	38.7 kb	Distal (>10kb) Multiome	636
chr19:17,305,286–17,306,514	40.9 kb	Distal (>10kb) Multiome	947
chr19:17,309,159–17,310,151	44.8 kb	Distal (>10kb) Multiome	741
chr19:17,327,532–17,329,548	63.2 kb	Distal (>10kb) Multiome	370
chr19:17,334,287–17,335,052	70.1 kb	Distal (>10kb) Multiome	870
chr19:17,336,574–17,338,240	72.7 kb	Distal (>10kb) Multiome	924
chr19:17,340,311–17,341,226	75.9 kb	Distal (>10kb) Multiome	419
chr19:17,390,414–17,391,521	126.4 kb	Distal (>10kb) Multiome	615
chr19:17,394,998–17,395,433	130.5 kb	Distal (>10kb) Multiome	403
chr19:17,398,863–17,399,537	134.5 kb	Distal (>10kb) Multiome	132
chr19:17,403,087–17,404,355	138.8 kb	Distal (>10kb) Multiome	211
chr19:17,419,503–17,420,821	155.2 kb	Distal (>10kb) Multiome	869
chr19:17,424,865–17,425,411	160.4 kb	Distal (>10kb) Multiome	328
chr19:17,448,174–17,448,841	183.9 kb	Distal (>10kb) Multiome	392
chr19:17,468,858–17,470,905	205.4 kb	Distal (>10kb) Multiome	743
chr19:17,488,739–17,489,689	224.4 kb	Distal (>10kb) Multiome	381
chr19:17,511,113–17,512,592	246.8 kb	Distal (>10kb) Multiome	1021
chr19:17,538,878–17,540,353	275.0 kb	Distal (>10kb) Multiome	725
chr19:17,555,194–17,556,523	290.8 kb	Distal (>10kb) Multiome	713

Genome Browser

Genomic view of the USHBP1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.